Joenja results
For children ages 4-11
Discover how Joenja was studied in children ages 4-11, and see results from the clinical trial.
Mariana, person living with APDS
How Joenja was studied in children 4+ years of age
Duration
12 weeks
Population
21 participants
Age
4-11
Dosing
Joenja was administered as 1 tablet twice a day, with doses ranging from 20 to 50 mg for 12 weeks
Conditions
This was an open-label, single-arm, international study to evaluate the safety and efficacy of Joenja in children ages 4-11
Joenja showed consistent improvements in lymph node reductions and meaningful improvements in B-cell function across all age groups
A reduction in lymph node size by week 12*
- Lymph node size was measured for each person before and after treatment with Joenja to compare the reduction in size
- The results showed that lymph nodes decreased in size for children taking Joenja
Reduction of swollen lymph nodes at week 12
33.8%
reduction in swollen lymph nodes
An increase in naïve B cells at 12 weeks
- Children in the clinical trial had their naïve B cells measured at 12 weeks
- A naïve B cell is a type of immune cell that has never been exposed to a foreign substance, such as a virus, bacteria, or other invaders
- The results showed an increase in naïve B cells with Joenja. An increase in naïve B cells can help the body fight infections
Increase in naïve B cells at week 12
8.6%
mean increase in naїve B cells
CFB, change from baseline.
Children 4-11 years old saw a decrease in spleen size at week 12 with Joenja
Decrease in spleen size at week 12*
- The spleen plays an important role in filtering out infections from our blood. When the spleen becomes enlarged, it may not function properly
25% decrease in spleen size
*At week 12, mean spleen volume decreased to 176.60 cm3 from 236.30 cm3 at baseline (n=21).
Possible side effects of Joenja for children 4-11
If you have concerns or would like to know more about potential side effects, please talk with your doctor about Joenja.
Side effect
Joenja
21 participants
n (%)
Sinus infection
11
(52.4)
Vomiting
4
(19.0)
Diarrhea
3
(14.3)
Headache
6
(28.6)
Fever
6
(28.6)
Cough
4
(19.0)
Skin rash
4
(19.0)
APDS, activated PI3K delta syndrome; SPD, sum of product diameters.
Learn more about taking Joenja
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